Effects of bioactive substances isolated from Siberian medicinal plants on the lifespan of Caenorhabditis elegans

Medicinal plants are sources of natural antioxidants. Acting as reducing agents, these substances protect the human body against oxidative stress and slow down aging process. We aimed to study effects bioactive isolated from medicinal on lifespan Caenorhabditis elegans L. used a model organism.
 High-performance liquid chromatography was applied isolate extracts callus, suspension, root cultures meadowsweet (Filipendula ulmaria L.), ginkgo (Ginkgo biloba Baikal skullcap (Scutellaria baicalensis red clover (Trifolium pretense alfalfa (Medicágo sativa thyme (Thymus vulgaris L.). Their effect C. nematodes determined by counting live treated with their concentrations 10, 50, 100, 200 µmol/L after 61 days experiment. The results were recorded using IR spectrometry.
 at least 95% pure. found that studied trans-cinnamic acid, baicalin, rutin, ursolic magniferin did not significantly increase nematodes. Naringenin increased an average 27.3% during 8–26. Chlorogenic acid concentration 100 27.7%. Ginkgo-based kaempferol quercetin, well clover-based biochanin A 200, µmol/L, respectively, 30.6, 41.9, 45.2%, respectively.
 produced root, suspension above had positive This confirms geroprotective properties allows them be anti-aging agents.